Statistical methods for the blood beryllium lymphocyte proliferation test.
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چکیده
منابع مشابه
Statistical methods for the blood beryllium lymphocyte proliferation test.
The blood beryllium lymphocyte proliferation test (BeLPT) is a modification of the standard lymphocyte proliferation test that is used to identify persons who may have chronic beryllium disease. A major problem in the interpretation of BeLPT test results is outlying data values among the replicate well counts (approximately 7%). A long-linear regression model is used to describe the expected we...
متن کاملSignificance of the blood beryllium lymphocyte proliferation test.
The blood beryllium lymphocyte proliferation test (BeLPT) is an in vitro measure of the beryllium antigen-specific cell-mediated immune response. This response to beryllium is now understood to play a central role in the immunopathogenesis of chronic beryllium disease (CBD). Although there remain some unresolved methodologic issues with testing, the blood BeLPT has already undergone sufficient ...
متن کاملAssessment of the beryllium lymphocyte proliferation test using statistical process control.
Despite more than 20 years of surveillance and epidemiologic studies using the beryllium blood lymphocyte proliferation test (BeBLPT) as a measure of beryllium sensitization (BeS) and as an aid for diagnosing subclinical chronic beryllium disease (CBD), improvements in specific understanding of the inhalation toxicology of CBD have been limited. Although epidemiologic data suggest that BeS and ...
متن کاملPerformance of the beryllium blood lymphocyte proliferation test based on a long-term occupational surveillance program.
OBJECTIVE Data from surveys of the general workforce and new employees at a beryllium manufacturer were used to evaluate the performance of the beryllium blood lymphocyte proliferation test (BeBLPT). METHODS Over 10,000 results from nearly 2,400 participants collected over 12 years were analyzed using consistent criteria to describe the performance characteristics of the BeBLPT. RESULTS App...
متن کاملIdentification of an abnormal beryllium lymphocyte proliferation test.
The potential hazards from exposure to beryllium or beryllium compounds in the workplace were first reported in the 1930s. The tritiated thymidine beryllium lymphocyte proliferation test (BeLPT) is an in vitro blood test that is widely used to screen beryllium exposed workers in the nuclear industry for sensitivity to beryllium. The clinical significance of the BeLPT was described and a standar...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.96104s5957